• Long-Term Ambient Air Pollutio...

*Result*: Long-Term Ambient Air Pollution Exposures and Brain Imaging Markers in Korean Adults: The Environmental Pollution-Induced Neurological Effects (EPINEF) Study.

Title:
Long-Term Ambient Air Pollution Exposures and Brain Imaging Markers in Korean Adults: The Environmental Pollution-Induced Neurological Effects (EPINEF) Study.
Authors:
Jaelim Cho1,2,3, Young Noh4, Sun Young Kim5, Jungwoo Sohn6, Juhwan Noh7, Woojin Kim7, Seong-Kyung Cho7, Hwasun Seo7, Gayoung Seo7, Seung-Koo Lee8, Seongho Seo9,10, Sang-Baek Koh11, Sung Soo Oh11, Hee Jin Kim12, Sang Won Seo12, Dae-Seock Shin13, Nakyoung Kim13, Ho Hyun Kim14, Jung Il Lee15, Changsoo Kim2,3,7 preman@yuhs.ac
Source:
Environmental Health Perspectives. Nov2020, Vol. 128 Issue 11, p117006-1-117006-11. 11p. 1 Color Photograph, 5 Charts.
Subject Terms:
*Animal experimentation, *RNA, *Water pollution, *Environmental exposure, Embryonic physiology, Eggs, Analysis of variance, Cellular signal transduction, Statistical correlation, Estrogen, Factor analysis, Fisher exact test, Follicle-stimulating hormone, Genomes, Gonads, Ovarian follicle, Human growth, Multidimensional scaling, Polymerase chain reaction, Reptiles, Research funding, Statistics, T-test (Statistics), Transcription factors, Phenotypes, Data analysis, Endocrine system, Ontologies (Information retrieval), Gene expression profiling, Sequence analysis, One-way analysis of variance
Geographic Terms:
Florida
Database:
GreenFILE

*Further Information*

*BACKGROUND: Only a limited number of neuroimaging studies have explored the effects of ambient air pollution in adults. The prior studies have investigated only cortical volume, and they have reported mixed findings, particularly for gray matter. Furthermore, the association between nitrogen dioxide (NO2) and neuroimaging markers has been little studied in adults. OBJECTIVES: We investigated the association between long-term exposure to air pollutants (NO2, particulate matter (PM) with aerodynamic diameters of =10 µm (PM10) and =2.5 µm (PM2.5), and neuroimaging markers. RESULTS: A 10-µg/m³ increase in PM10 was associated with reduced thicknesses in the frontal [–0.02 mm (95% CI: –0.03, –0.01)] and temporal lobes [–0.06 mm (95% CI: –0.07, –0.04)]. A 10-µg/m³ increase in PM2.5 was associated with a thinner temporal cortex [–0.18 mm (95% CI: –0.27, –0.08)]. A 10-ppb increase in NO2 was associated with reduced thicknesses in the global [–0.01 mm (95% CI: –0.01, 0.00)], frontal [–0.02 mm (95% CI: –0.03, –0.01)], parietal [–0.02 mm (95% CI: –0.03, –0.01)], temporal [–0.04 mm (95% CI: –0.05, –0.03)], and insular lobes [–0.01 mm (95% CI: –0.02, 0.00)]. The air pollutants were also associated with increased thicknesses in the occipital and cingulate lobes. Subcortical structures associated with the air pollutants included the thalamus, caudate, pallidum, hippocampus, amygdala, and nucleus accumbens. DISCUSSION: The findings suggest that long-term exposure to high ambient air pollution may lead to cortical thinning and reduced subcortical volume in adults. [ABSTRACT FROM AUTHOR]

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