Treffer: Investigation of central pattern generators in the spinal cord of chicken embryos.
Title:
Investigation of central pattern generators in the spinal cord of chicken embryos.
Authors:
Gutiérrez-Ibáñez C; Department of Biological Sciences, University of Alberta, Edmonton, AB, T6G 2E0, Canada. cgutierr@ualberta.ca.; Grass Laboratory, Marine Biological Laboratory, Woods Hole, MA, USA. cgutierr@ualberta.ca., Wylie DR; Department of Biological Sciences, University of Alberta, Edmonton, AB, T6G 2E0, Canada.
Source:
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology [J Comp Physiol A Neuroethol Sens Neural Behav Physiol] 2024 Sep; Vol. 210 (5), pp. 801-814. Date of Electronic Publication: 2024 Mar 23.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Springer Country of Publication: Germany NLM ID: 101141792 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1351 (Electronic) Linking ISSN: 03407594 NLM ISO Abbreviation: J Comp Physiol A Neuroethol Sens Neural Behav Physiol Subsets: MEDLINE
Imprint Name(s):
Original Publication: Berlin ; New York : Springer, c2001-
MeSH Terms:
Spinal Cord*/physiology , Central Pattern Generators*/physiology , Serotonin*/metabolism , Serotonin*/pharmacology , N-Methylaspartate*/pharmacology , N-Methylaspartate*/metabolism, Wings, Animal/physiology ; Locomotion/physiology ; Hindlimb/physiology ; Hindlimb/innervation ; Motor Neurons/physiology ; Action Potentials/physiology ; Animals ; Chick Embryo ; Periodicity
References:
Acta Biol Acad Sci Hung. 1963;14:143-53. (PMID: 14107527)
Annu Rev Cell Dev Biol. 2015;31:669-98. (PMID: 26393773)
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14098-103. (PMID: 16172411)
Brain Res Dev Brain Res. 1990 Oct 1;56(1):13-8. (PMID: 2279325)
J Physiol. 1958 Oct 31;143(3):541-52. (PMID: 13588572)
Dev Psychobiol. 1980 Mar;13(2):151-63. (PMID: 7358220)
J Neurosci. 1996 Jan;16(1):298-306. (PMID: 8613795)
J Neurophysiol. 1995 Mar;73(3):1223-33. (PMID: 7608767)
J Neurosci. 1987 Oct;7(10):3256-64. (PMID: 3668626)
Nature. 2013 Aug 1;500(7460):85-8. (PMID: 23812590)
J Neurophysiol. 2005 Jun;93(6):3120-6. (PMID: 15728760)
Curr Opin Neurobiol. 1999 Oct;9(5):628-33. (PMID: 10508740)
Syst Biol. 2020 Sep 1;69(5):962-972. (PMID: 32101317)
Sci Adv. 2021 Jun 11;7(24):. (PMID: 34117069)
Annu Rev Neurosci. 2006;29:279-306. (PMID: 16776587)
J Neurosci. 1984 Nov;4(11):2659-66. (PMID: 6542130)
Eur J Neurosci. 2011 Oct;34(7):1102-12. (PMID: 21899605)
J Physiol. 1992 Sep;455:187-204. (PMID: 1362441)
J Neurophysiol. 2006 Aug;96(2):642-51. (PMID: 16641385)
J Exp Biol. 2018 Jun 15;221(Pt 12):. (PMID: 29907573)
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2007 Dec;193(12):1177-83. (PMID: 17987297)
Brain Res Bull. 2000 Nov 15;53(5):719-26. (PMID: 11165806)
Philos Trans R Soc Lond B Biol Sci. 2016 Jan 5;371(1685):20150057. (PMID: 26598733)
J Neurosci. 2014 Mar 12;34(11):3841-53. (PMID: 24623763)
Brain Res Bull. 2000 Nov 15;53(5):689-710. (PMID: 11165804)
Genes Dev. 2001 Apr 1;15(7):877-88. (PMID: 11297511)
J Neurophysiol. 1994 Oct;72(4):1810-29. (PMID: 7823103)
Brain Res Bull. 2000 Nov 15;53(5):711-8. (PMID: 11165805)
J Physiol. 1997 Aug 15;503 ( Pt 1):111-7. (PMID: 9288679)
Science. 2003 Mar 21;299(5614):1889-92. (PMID: 12649481)
J Biol Chem. 2006 Feb 17;281(7):3841-55. (PMID: 16344549)
J Neurobiol. 1990 Jun;21(4):651-60. (PMID: 2376735)
J Neurosci. 2017 Nov 8;37(45):10835-10841. (PMID: 29118212)
J Exp Zool. 1992 Mar 1;261(3):261-73. (PMID: 1629659)
J Neurobiol. 1992 Dec;23(10):1486-505. (PMID: 1487746)
J Neurophysiol. 2020 Jun 1;123(6):2326-2342. (PMID: 32401145)
J Exp Zool. 1971 Dec;178(4):415-31. (PMID: 5161044)
J Physiol. 1975 Jul;249(2):301-26. (PMID: 1177095)
J Neurosci. 1997 Jan 15;17(2):625-34. (PMID: 8987785)
Exp Brain Res. 1995;103(2):218-26. (PMID: 7789429)
Elife. 2020 Sep 09;9:. (PMID: 32902379)
Curr Opin Neurobiol. 1999 Feb;9(1):94-104. (PMID: 10072366)
Ann N Y Acad Sci. 1998 Nov 16;860:467-9. (PMID: 9928341)
Proc Biol Sci. 1997 Jun 22;264(1383):877-84. (PMID: 9225479)
Brain Res. 1976 Apr 23;106(2):271-91. (PMID: 1276872)
J Comp Neurol. 1990 Dec 15;302(3):575-88. (PMID: 1702118)
Front Neural Circuits. 2010 Aug 06;4:. (PMID: 20844601)
Brain Res. 1987 Dec 1;433(2):271-6. (PMID: 2891412)
J Neurosci. 1990 Aug;10(8):2699-716. (PMID: 2167355)
Brain Res Brain Res Rev. 2002 Oct;40(1-3):107-17. (PMID: 12589910)
Dev Biol. 2012 Jun 15;366(2):279-89. (PMID: 22521513)
J Neurosci. 1993 Apr;13(4):1354-71. (PMID: 8463824)
J Neurosci. 2009 Dec 16;29(50):15642-9. (PMID: 20016078)
J Neurosci. 1995 Jul;15(7 Pt 1):4943-51. (PMID: 7623124)
Exp Brain Res. 1971 Jun 29;12(5):547-65. (PMID: 5093729)
Vis Neurosci. 2007 Jul-Aug;24(4):513-21. (PMID: 17659095)
Ann N Y Acad Sci. 1998 Nov 16;860:110-29. (PMID: 9928306)
Proc Natl Acad Sci U S A. 1973 Oct;70(10):2832-6. (PMID: 4200724)
J Physiol. 1969 Nov;205(2):377-91. (PMID: 5357245)
J Comp Neurol. 1980 Nov 1;194(1):143-70. (PMID: 7192292)
J Exp Biol. 1985 May;116:27-46. (PMID: 4056654)
J Neurosci. 2009 Aug 19;29(33):10387-95. (PMID: 19692613)
Eur J Neurosci. 2000 Mar;12(3):994-1001. (PMID: 10762330)
Neurosci Lett. 1993 Aug 20;158(2):139-42. (PMID: 8233086)
J Neurophysiol. 1997 Mar;77(3):1155-70. (PMID: 9084588)
Evolution. 1996 Feb;50(1):331-340. (PMID: 28568886)
Annu Rev Cell Dev Biol. 2015;31:669-98. (PMID: 26393773)
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14098-103. (PMID: 16172411)
Brain Res Dev Brain Res. 1990 Oct 1;56(1):13-8. (PMID: 2279325)
J Physiol. 1958 Oct 31;143(3):541-52. (PMID: 13588572)
Dev Psychobiol. 1980 Mar;13(2):151-63. (PMID: 7358220)
J Neurosci. 1996 Jan;16(1):298-306. (PMID: 8613795)
J Neurophysiol. 1995 Mar;73(3):1223-33. (PMID: 7608767)
J Neurosci. 1987 Oct;7(10):3256-64. (PMID: 3668626)
Nature. 2013 Aug 1;500(7460):85-8. (PMID: 23812590)
J Neurophysiol. 2005 Jun;93(6):3120-6. (PMID: 15728760)
Curr Opin Neurobiol. 1999 Oct;9(5):628-33. (PMID: 10508740)
Syst Biol. 2020 Sep 1;69(5):962-972. (PMID: 32101317)
Sci Adv. 2021 Jun 11;7(24):. (PMID: 34117069)
Annu Rev Neurosci. 2006;29:279-306. (PMID: 16776587)
J Neurosci. 1984 Nov;4(11):2659-66. (PMID: 6542130)
Eur J Neurosci. 2011 Oct;34(7):1102-12. (PMID: 21899605)
J Physiol. 1992 Sep;455:187-204. (PMID: 1362441)
J Neurophysiol. 2006 Aug;96(2):642-51. (PMID: 16641385)
J Exp Biol. 2018 Jun 15;221(Pt 12):. (PMID: 29907573)
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2007 Dec;193(12):1177-83. (PMID: 17987297)
Brain Res Bull. 2000 Nov 15;53(5):719-26. (PMID: 11165806)
Philos Trans R Soc Lond B Biol Sci. 2016 Jan 5;371(1685):20150057. (PMID: 26598733)
J Neurosci. 2014 Mar 12;34(11):3841-53. (PMID: 24623763)
Brain Res Bull. 2000 Nov 15;53(5):689-710. (PMID: 11165804)
Genes Dev. 2001 Apr 1;15(7):877-88. (PMID: 11297511)
J Neurophysiol. 1994 Oct;72(4):1810-29. (PMID: 7823103)
Brain Res Bull. 2000 Nov 15;53(5):711-8. (PMID: 11165805)
J Physiol. 1997 Aug 15;503 ( Pt 1):111-7. (PMID: 9288679)
Science. 2003 Mar 21;299(5614):1889-92. (PMID: 12649481)
J Biol Chem. 2006 Feb 17;281(7):3841-55. (PMID: 16344549)
J Neurobiol. 1990 Jun;21(4):651-60. (PMID: 2376735)
J Neurosci. 2017 Nov 8;37(45):10835-10841. (PMID: 29118212)
J Exp Zool. 1992 Mar 1;261(3):261-73. (PMID: 1629659)
J Neurobiol. 1992 Dec;23(10):1486-505. (PMID: 1487746)
J Neurophysiol. 2020 Jun 1;123(6):2326-2342. (PMID: 32401145)
J Exp Zool. 1971 Dec;178(4):415-31. (PMID: 5161044)
J Physiol. 1975 Jul;249(2):301-26. (PMID: 1177095)
J Neurosci. 1997 Jan 15;17(2):625-34. (PMID: 8987785)
Exp Brain Res. 1995;103(2):218-26. (PMID: 7789429)
Elife. 2020 Sep 09;9:. (PMID: 32902379)
Curr Opin Neurobiol. 1999 Feb;9(1):94-104. (PMID: 10072366)
Ann N Y Acad Sci. 1998 Nov 16;860:467-9. (PMID: 9928341)
Proc Biol Sci. 1997 Jun 22;264(1383):877-84. (PMID: 9225479)
Brain Res. 1976 Apr 23;106(2):271-91. (PMID: 1276872)
J Comp Neurol. 1990 Dec 15;302(3):575-88. (PMID: 1702118)
Front Neural Circuits. 2010 Aug 06;4:. (PMID: 20844601)
Brain Res. 1987 Dec 1;433(2):271-6. (PMID: 2891412)
J Neurosci. 1990 Aug;10(8):2699-716. (PMID: 2167355)
Brain Res Brain Res Rev. 2002 Oct;40(1-3):107-17. (PMID: 12589910)
Dev Biol. 2012 Jun 15;366(2):279-89. (PMID: 22521513)
J Neurosci. 1993 Apr;13(4):1354-71. (PMID: 8463824)
J Neurosci. 2009 Dec 16;29(50):15642-9. (PMID: 20016078)
J Neurosci. 1995 Jul;15(7 Pt 1):4943-51. (PMID: 7623124)
Exp Brain Res. 1971 Jun 29;12(5):547-65. (PMID: 5093729)
Vis Neurosci. 2007 Jul-Aug;24(4):513-21. (PMID: 17659095)
Ann N Y Acad Sci. 1998 Nov 16;860:110-29. (PMID: 9928306)
Proc Natl Acad Sci U S A. 1973 Oct;70(10):2832-6. (PMID: 4200724)
J Physiol. 1969 Nov;205(2):377-91. (PMID: 5357245)
J Comp Neurol. 1980 Nov 1;194(1):143-70. (PMID: 7192292)
J Exp Biol. 1985 May;116:27-46. (PMID: 4056654)
J Neurosci. 2009 Aug 19;29(33):10387-95. (PMID: 19692613)
Eur J Neurosci. 2000 Mar;12(3):994-1001. (PMID: 10762330)
Neurosci Lett. 1993 Aug 20;158(2):139-42. (PMID: 8233086)
J Neurophysiol. 1997 Mar;77(3):1155-70. (PMID: 9084588)
Evolution. 1996 Feb;50(1):331-340. (PMID: 28568886)
Contributed Indexing:
Keywords: Avian; CPG; Connectivity; Interneuron; Locomotion; Neural circuit
Substance Nomenclature:
333DO1RDJY (Serotonin)
6384-92-5 (N-Methylaspartate)
6384-92-5 (N-Methylaspartate)
Entry Date(s):
Date Created: 20240324 Date Completed: 20240909 Latest Revision: 20240912
Update Code:
20260130
PubMed Central ID:
PMC11384640
DOI:
10.1007/s00359-024-01694-6
PMID:
38521869
Database:
MEDLINE
Weitere Informationen
For most quadrupeds, locomotion involves alternating movements of the fore- and hindlimbs. In birds, however, while walking generally involves alternating movements of the legs, to generate lift and thrust, the wings are moved synchronously with each other. Neural circuits in the spinal cord, referred to as central pattern generators (CPGs), are the source of the basic locomotor rhythms and patterns. Given the differences in the patterns of movement of the wings and legs, it is likely that the neuronal components and connectivity of the CPG that coordinates wing movements differ from those that coordinate leg movements. In this study, we used in vitro preparations of embryonic chicken spinal cords (E11-E14) to compare the neural responses of spinal CPGs that control and coordinate wing flapping with those that control alternating leg movements. We found that in response to N-methyl-D-aspartate (NMDA) or a combination of NMDA and serotonin (5-HT), the intact chicken spinal cord produced rhythmic outputs that were synchronous both bilaterally and between the wing and leg segments. Despite this, we found that this rhythmic output was disrupted by an antagonist of glycine receptors in the lumbosacral (legs), but not the brachial (wing) segments. Thus, our results provide evidence of differences between CPGs that control the wings and legs in the spinal cord of birds.
(© 2024. The Author(s).)