• The mammalian locomotor CPG: r...

*Result*: The mammalian locomotor CPG: revealing the contents of the black box.

Title:
The mammalian locomotor CPG: revealing the contents of the black box.
Authors:
Gosgnach S; Department of Physiology, University of Alberta, Edmonton, Alberta, Canada.; Women's and Children's Health Research Institute, University of Alberta, Edmonton, Alberta, Canada.
Source:
Journal of neurophysiology [J Neurophysiol] 2025 Feb 01; Vol. 133 (2), pp. 472-478. Date of Electronic Publication: 2024 Dec 20.
Publication Type:
Journal Article; Review
Language:
English
Journal Info:
Publisher: American Physiological Society Country of Publication: United States NLM ID: 0375404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1598 (Electronic) Linking ISSN: 00223077 NLM ISO Abbreviation: J Neurophysiol Subsets: MEDLINE
Imprint Name(s):
Publication: Bethesda Md : American Physiological Society
Original Publication: Washington [etc.]
MeSH Terms:
Locomotion*/physiology , Central Pattern Generators*/physiology , Spinal Cord*/physiology , Spinal Cord*/cytology, Interneurons/physiology ; Mammals/physiology ; Motor Neurons/physiology ; Animals ; Humans
Comments:
Comment in: J Neurophysiol. 2025 Jul 1;134(1):50-52. doi: 10.1152/jn.00208.2025.. (PMID: 40423682)
Grant Information:
MOP 86470 Canadian Government | Canadian Institutes of Health Research (CIHR); Women and Children's Health Research Institute / Stollery Children's Hospital Foundation
Contributed Indexing:
Keywords: CPG; locomotion
Entry Date(s):
Date Created: 20241220 Date Completed: 20250428 Latest Revision: 20250624
Update Code:
20260130
DOI:
10.1152/jn.00238.2024
PMID:
39704678
Database:
MEDLINE

*Further Information*

*It has long been known that a neural circuit situated in the spinal cord of mammals is independently capable of generating and modulating locomotor movements. Following its initial discovery over a century ago, a great deal of research has been focused on characterizing this neural circuit to determine how it is able to elicit movement. For much of the 20th century, difficulty in identifying individual component interneurons that comprised this neural circuit resulted in it being considered a powerful but mysterious "black box." In this article, we will review the development of a number of innovative experimental approaches that have brought us to the current state of research in the field, where we are able to identify populations that comprise this neural circuit, pinpoint their specific function, and image their activity in real time during a locomotor task.
(Copyright © 2025 The Authors.)*