• Convergent effects of peptides...

Treffer: Convergent effects of peptides on the initiation of feeding motor programs in the mollusk Aplysia.

Title:
Convergent effects of peptides on the initiation of feeding motor programs in the mollusk Aplysia.
Authors:
Evans CG; Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States., Barry MA; Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States., Reaver CN; Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States., Patel PR; Department of Biomedical Engineering, Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan, United States., Chestek CA; Department of Biomedical Engineering, Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan, United States.; Department of Electrical Engineering and Computer Science, Neurosciences Program, Robotics Program, University of Michigan, Ann Arbor, Michigan, United States., Perkins MH; Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States., Jing J; Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States.; State Key Laboratory of Pharmaceutical Biotechnology, Institute for Brain Sciences, Chemistry and Biomedicine Innovation Center, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, Advanced Institute for Life Sciences, School of Life Sciences, Nanjing University, Nanjing, China., Cropper EC; Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States.
Source:
Journal of neurophysiology [J Neurophysiol] 2025 May 01; Vol. 133 (5), pp. 1368-1379. Date of Electronic Publication: 2025 Apr 04.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: American Physiological Society Country of Publication: United States NLM ID: 0375404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1598 (Electronic) Linking ISSN: 00223077 NLM ISO Abbreviation: J Neurophysiol Subsets: MEDLINE
Imprint Name(s):
Publication: Bethesda Md : American Physiological Society
Original Publication: Washington [etc.]
MeSH Terms:
Aplysia*/physiology , Feeding Behavior*/physiology , Feeding Behavior*/drug effects , Neuropeptides*/pharmacology , Interneurons*/physiology , Interneurons*/drug effects , Central Pattern Generators*/physiology , Central Pattern Generators*/drug effects, Ganglia, Invertebrate/physiology ; Animals
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Grant Information:
R01 NS070583 United States NS NINDS NIH HHS; NS070583 HHS | National Institutes of Health (NIH); RF1 NS118606 United States NS NINDS NIH HHS; 31861143036 | National Natural Science Foundation of China-Guangdong Joint Fund (-); R01 NS066587 United States NS NINDS NIH HHS; NS118606 HHS | National Institutes of Health (NIH); 32171011 | National Natural Science Foundation of China-Guangdong Joint Fund (-); R01 NS118606 United States NS NINDS NIH HHS; 31371104 | National Natural Science Foundation of China-Guangdong Joint Fund (-); NS066587 HHS | National Institutes of Health (NIH); 31671097 | National Natural Science Foundation of China-Guangdong Joint Fund (-)
Contributed Indexing:
Keywords: central pattern generator; invertebrate; modulation; motor program; neuropeptide
Substance Nomenclature:
0 (Neuropeptides)
Entry Date(s):
Date Created: 20250404 Date Completed: 20250422 Latest Revision: 20250524
Update Code:
20260130
PubMed Central ID:
PMC12096845
DOI:
10.1152/jn.00042.2025
PMID:
40183430
Database:
MEDLINE

Weitere Informationen

Neuropeptides configure the feeding network of Aplysia. For example, egestive activity is promoted by small cardioactive peptide (SCP), and ingestive activity is promoted by a combination of feeding circuit activating peptide (FCAP) and cerebral peptide 2 (CP-2). In addition, SCP and FCAP/CP-2 have a common network effect that does not contribute to motor program specification. They increase the excitability of an interneuron, B63. In this report, we further characterized the effects of peptides on B63. We performed voltage-clamp experiments and used a step protocol to look at steady-state currents. We found that SCP and FCAP/CP-2 both induced an inward current that was virtually absent in low-sodium saline. Previous work has established that B63 is unusual in the feeding circuit in that subthreshold depolarizations are autonomously generated that can trigger motor programs. Here, we show that this autonomous activity is more frequent in the presence of peptides. Previous studies have also shown that activity of the feeding central pattern generator (CPG) can be initiated by neurons that excite B63, e.g., by cerebral buccal interneuron 2 (CBI-2), a projection neuron that triggers biting-like motor programs. Here, we show that the latency of CBI-2-induced activity is decreased by stimulation of the esophageal nerve (EN) (which releases endogenous SCP). These results, taken together with previous results, indicate that peptides that act divergently to configure network activity additionally act convergently to promote motor program induction. We present data that suggest that this arrangement facilitates brief switches between ingestive and egestive motor activity.NEW & NOTEWORTHY The activity of most networks is affected by multiple neuromodulators. Studies that have sought to determine why this is the case have focused on how the effects of one modulator differ from those of another (how modulators uniquely determine motor output). This study differs in that we ask why a convergent (common) network modification is important. We show that it can promote program induction and present data that suggest this may have consequences for task switching.