*Result*: A holistic framework for strengthening security of healthcare data through encryption utilizing blockchain technology.

Title:
A holistic framework for strengthening security of healthcare data through encryption utilizing blockchain technology.
Authors:
Venkataradhakrishnamurty P; Department of Computer Science and Engineering, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India. murthypokuri1982@gmail.com., Malathi K; Department of Computer Science and Engineering, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.
Source:
Scientific reports [Sci Rep] 2025 Dec 18; Vol. 16 (1), pp. 2008. Date of Electronic Publication: 2025 Dec 18.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Imprint Name(s):
Original Publication: London : Nature Publishing Group, copyright 2011-
References:
Appl Health Econ Health Policy. 2018 Oct;16(5):583-590. (PMID: 30022440)
Int J Environ Res Public Health. 2021 Jan 01;18(1):. (PMID: 33401373)
Sensors (Basel). 2022 Jun 26;22(13):. (PMID: 35808325)
Sensors (Basel). 2022 Feb 10;22(4):. (PMID: 35214273)
IEEE/ACM Trans Comput Biol Bioinform. 2019 Jul-Aug;16(4):1328-1341. (PMID: 30010584)
J Med Syst. 2018 May 4;42(6):112. (PMID: 29728780)
Sensors (Basel). 2022 Jan 12;22(2):. (PMID: 35062530)
Contributed Indexing:
Keywords: Blockchain-Based encryption; Convolutional neural networks; Decision trees; Healthcare cyber security; Logistic regression
Entry Date(s):
Date Created: 20251217 Date Completed: 20260115 Latest Revision: 20260118
Update Code:
20260130
PubMed Central ID:
PMC12808656
DOI:
10.1038/s41598-025-31698-4
PMID:
41407846
Database:
MEDLINE

*Further Information*

*Healthcare data security is increasingly critical due to the sensitive nature of patient information and the rising prevalence of cyber-attacks on medical systems. Existing techniques to security enhancement are evaluated, demonstrating their limits and emphasizing the urgent need for novel solutions. To address these issues, this study proposes a Blockchain-integrated Advanced Encryption Standard (BCT-AES) framework to enhance the privacy, integrity, and security of healthcare data. The framework combines Convolutional Neural Networks (CNN) for feature extraction, Decision Tree (DT) and Logistic Regression (LR) for classification, and AES encryption integrated with blockchain technology to provide a decentralized, tamper-proof storage solution. In this hybrid design, CNN extracts meaningful patterns from patient records and medical images, which are then classified by DT and LR models to facilitate predictive analytics while maintaining data confidentiality. Sensitive information is encrypted using AES before being recorded on the blockchain, ensuring robust access control and immutability. It further strengthens the data security and integrity when applied with AES. The results are carried out with Python software, meaning the proposed method has practicality in real life. The performance of the proposed BCT-AES framework was quantitatively validated, showing an average encryption time of 1.12 milliseconds, significantly outperforming existing methods such as AES-CP-IDABE (10.52 ms), Enhanced AES (20.9 ms), and AES-CBC (2.4 ms). Additionally, the framework demonstrated high classification accuracies, with DT achieving 99% and LR achieving 89%, indicating reliable predictive capabilities. By integrating deep learning with advanced encryption and blockchain, the proposed approach offers a practical and efficient solution for secure healthcare data management, supporting real-time analytics while preserving patient privacy.
(© 2025. The Author(s).)*

*Declarations. Competing interests: The authors declare no competing interests. Consent to publish: All the authors gave permission to Consent to publish.*