Treffer: Gas Plasma-Derived Reactive Species for Oxidative and Biomaterial Modifications-Smart Chemistry Enabling Biomedical Applications.
Title:
Gas Plasma-Derived Reactive Species for Oxidative and Biomaterial Modifications-Smart Chemistry Enabling Biomedical Applications.
Authors:
Ahmadi M; Leibniz Institute for Plasma Science and Technology (INP), Greifswald, Germany., Wende K; Leibniz Institute for Plasma Science and Technology (INP), Greifswald, Germany., Weltmann KD; Leibniz Institute for Plasma Science and Technology (INP), Greifswald, Germany., Clemen R; Leibniz Institute for Plasma Science and Technology (INP), Greifswald, Germany., Bekeschus S; Leibniz Institute for Plasma Science and Technology (INP), Greifswald, Germany.; Department of Dermatology, Venereology, and Allergology, Rostock University Medical Center, Rostock, Germany.
Source:
Advanced healthcare materials [Adv Healthc Mater] 2026 Mar; Vol. 15 (11), pp. e04558. Date of Electronic Publication: 2025 Dec 18.
Publication Type:
Journal Article; Review
Language:
English
Journal Info:
Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE
Imprint Name(s):
Original Publication: Weinheim : Wiley-VCH, 2012-
MeSH Terms:
References:
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Contributed Indexing:
Keywords: biomedicine; functional materials; gas plasma; modifications; nanomaterials; reactive species
Substance Nomenclature:
0 (Biocompatible Materials)
0 (Plasma Gases)
0 (Reactive Oxygen Species)
0 (Reactive Nitrogen Species)
0 (Plasma Gases)
0 (Reactive Oxygen Species)
0 (Reactive Nitrogen Species)
Entry Date(s):
Date Created: 20251219 Date Completed: 20260321 Latest Revision: 20260321
Update Code:
20260321
DOI:
10.1002/adhm.202504558
PMID:
41414651
Database:
MEDLINE
Weitere Informationen
Cold gas plasma chemistry facilitates biological and medical applications through the generation of reactive oxygen and nitrogen species (ROS/RNS), which interact with both materials and biological systems. At the materials level, plasma-derived reactive species modify surfaces such as hydrogels, scaffolds, nanomaterials, and inorganic substrates, thereby altering their physicochemical properties and improving how these materials interface with cells or tissues. At the biological level, reactive species can interact with (bio)molecules, ROS-responsive biomaterials, and cellular pathways, modulating redox signaling, immune responses, or metabolic processes. These modes of action apply in different contexts: plasma can modify materials before biological use or influence biomaterials as well as cells and tissues as a biological stimulus or co-therapeutic. This review covers recent advances in plasma-induced chemical transformations and discusses the dual role of plasma as a molecular engineering platform and co-therapeutic agent. Looking ahead, spatiotemporal control of ROS/RNS generation will be key not only for designing next-generation functional materials but also for local programming of cells in situ by modulating signaling pathways, immunometabolism, and tissue microenvironments to facilitate on-demand scaffold activation, selective antimicrobial/antitumor actions, and precision tissue regeneration. These capabilities highlight the growing promise of plasma technologies in advanced biomedicine.
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