• [Closed-loop regulation system...

*Result*: [Closed-loop regulation system for paralyzed lower limb joint movement based on electrical stimulation of spinal central pattern generator].

Title:
[Closed-loop regulation system for paralyzed lower limb joint movement based on electrical stimulation of spinal central pattern generator].
Authors:
Shen X; School of Information Science and Technology, Nantong University, Nantong, Jiangsu 226019, P. R. China.; Yancheng Tongzhou Orthopedic Hospital, Yancheng, Jiangsu 224002, P. R. China., Zhang X; School of Information Science and Technology, Nantong University, Nantong, Jiangsu 226019, P. R. China., Lou X; School of Information Science and Technology, Nantong University, Nantong, Jiangsu 226019, P. R. China., Gu H; School of Information Science and Technology, Nantong University, Nantong, Jiangsu 226019, P. R. China., Bian X; School of Information Science and Technology, Nantong University, Nantong, Jiangsu 226019, P. R. China., Zhong H; School of Information Science and Technology, Nantong University, Nantong, Jiangsu 226019, P. R. China., Zhao Y; Yancheng Tongzhou Orthopedic Hospital, Yancheng, Jiangsu 224002, P. R. China.; Suzhou Shenchen Medical Technology Co., Suzhou, Jiangsu 215004, P. R. China.
Source:
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi [Sheng Wu Yi Xue Gong Cheng Xue Za Zhi] 2025 Dec 25; Vol. 42 (6), pp. 1131-1138.
Publication Type:
English Abstract; Journal Article
Language:
Chinese
Journal Info:
Publisher: Sichuan Sheng sheng wu yi xue gong cheng xue hui Country of Publication: China NLM ID: 9426398 Publication Model: Print Cited Medium: Print ISSN: 1001-5515 (Print) Linking ISSN: 10015515 NLM ISO Abbreviation: Sheng Wu Yi Xue Gong Cheng Xue Za Zhi Subsets: MEDLINE
Imprint Name(s):
Publication: Chengdu : Sichuan Sheng sheng wu yi xue gong cheng xue hui
Original Publication: Chengdu : Sichuan Sheng sheng wu yi xue gong cheng xue hui : Hua xi yi ke da xue : Chengdu ke ji da xue
MeSH Terms:
Spinal Cord Injuries*/physiopathology , Spinal Cord Injuries*/rehabilitation , Electric Stimulation Therapy*/methods , Central Pattern Generators*/physiology , Paralysis*/physiopathology , Paralysis*/rehabilitation , Ankle Joint*/physiopathology, Hindlimb/physiopathology ; Lower Extremity/physiopathology ; Animals ; Rats ; Algorithms ; Fuzzy Logic ; Movement ; Electric Stimulation ; Spinal Cord ; Male
References:
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Contributed Indexing:
Keywords: Central pattern generator; Control strategy; Intraspinal microstimulation
Local Abstract: [Publisher, Chinese] 脊髓内微刺激技术是一种通过电刺激脊髓进而激活肌肉运动，从而恢复瘫痪肢体的康复技术。本文采用模糊逻辑控制型自整定比例-积分-微分算法，通过同时调节脉冲信号的幅值、脉宽和频率三个关键电刺激参数，激励脊髓损伤大鼠远端的步行中枢模式发生器，实现瘫痪大鼠后肢踝关节运动的实时调控。为了验证脊髓内微刺激系统的控制性能，开展了动物实验，经统计，关节角跟踪均方根误差为2.50°和归一化均方根误差为5.78%。结果表明，通过单电极脊髓内电刺激，脊髓损伤大鼠瘫痪后肢踝关节能按预设的角度轨迹运动。.
Entry Date(s):
Date Created: 20251225 Date Completed: 20251225 Latest Revision: 20251231
Update Code:
20260130
PubMed Central ID:
PMC12744980
DOI:
10.7507/1001-5515.202411040
PMID:
41448754
Database:
MEDLINE

*Further Information*

*Intraspinal microstimulation (ISMS) is a rehabilitation technology that activates muscle movement by electrically stimulating the spinal cord, thereby restoring the function of paralyzed limbs. In this study, a fuzzy logic-controlled self-tuning proportional-integral-derivative (PID) algorithm was adopted. By simultaneously adjusting three key electrical stimulation parameters-amplitude, pulse width, and frequency of the pulse signal-the distal locomotor central pattern generator (CPG) in rats with spinal cord injury (SCI) was activated, realizing real-time control of hindlimb ankle joint movement in paralyzed rats. To verify the control performance of the intraspinal microstimulation system, animal experiments were conducted. Statistical results showed that the root mean square error (RMSE) of joint angle tracking was 2.50°, and the normalized root mean square error (NRMSE) was 5.78%. The results indicate that the ankle joint of the paralyzed hindlimb in SCI rats can move according to the preset angle trajectory through single-electrode intraspinal electrical stimulation.*