• PRRs-related genes and immune...

Treffer: PRRs-related genes and immune landscape in heart failure and COPD.

Title:
PRRs-related genes and immune landscape in heart failure and COPD.
Authors:
Yang H; Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China., Mei T; First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China. meitingting@hljucm.edu.cn.; Postdoctoral Mobile Station of Integrated Traditional Chinese and Western Medicine, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China. meitingting@hljucm.edu.cn.
Source:
Scientific reports [Sci Rep] 2026 Jan 06; Vol. 16 (1), pp. 4557. Date of Electronic Publication: 2026 Jan 06.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Imprint Name(s):
Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:
Pulmonary Disease, Chronic Obstructive*/genetics , Pulmonary Disease, Chronic Obstructive*/immunology , Heart Failure*/genetics , Heart Failure*/immunology , Receptors, Pattern Recognition*/genetics , Receptors, Pattern Recognition*/metabolism, Humans ; Gene Expression Profiling ; Gene Expression Regulation ; Signal Transduction ; Databases, Genetic ; Transcriptome
References:
Circ Cardiovasc Genet. 2010 Apr;3(2):138-46. (PMID: 20124440)
Chronic Obstr Pulm Dis. 2024 Sep 27;11(5):482-495. (PMID: 39012715)
J Cell Mol Med. 2015 Dec;19(12):2728-40. (PMID: 26290459)
BMC Pulm Med. 2023 Apr 11;23(1):115. (PMID: 37041558)
Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. (PMID: 23193258)
Genome Res. 2003 Nov;13(11):2498-504. (PMID: 14597658)
BMC Bioinformatics. 2011 Mar 17;12:77. (PMID: 21414208)
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50. (PMID: 16199517)
Front Physiol. 2021 Dec 07;12:783396. (PMID: 34950055)
Int J Chron Obstruct Pulmon Dis. 2018 Aug 28;13:2643-2655. (PMID: 30214182)
J Hosp Med. 2020 Feb 11;15(4):240-241. (PMID: 32118561)
Curr Protoc Bioinformatics. 2016 Jun 20;54:1.30.1-1.30.33. (PMID: 27322403)
Drug Des Devel Ther. 2024 Apr 30;18:1415-1438. (PMID: 38707614)
ESC Heart Fail. 2025 Apr;12(2):900-911. (PMID: 39509556)
Comput Intell Neurosci. 2022 Apr 12;2022:7205016. (PMID: 35463266)
Curr Neuropharmacol. 2020;18(10):918-935. (PMID: 32031074)
BMC Genomics. 2024 Mar 5;25(1):245. (PMID: 38443809)
Bone Res. 2024 Sep 6;12(1):53. (PMID: 39242551)
OMICS. 2012 May;16(5):284-7. (PMID: 22455463)
Int J Chron Obstruct Pulmon Dis. 2023 Jun 10;18:1135-1144. (PMID: 37323542)
Bioinformatics. 2011 Jun 15;27(12):1739-40. (PMID: 21546393)
Altern Ther Health Med. 2022 Jan;28(1):44-51. (PMID: 34264858)
Sci Rep. 2017 Mar 13;7:44232. (PMID: 28287180)
Nat Methods. 2015 May;12(5):453-7. (PMID: 25822800)
Fish Shellfish Immunol. 2021 Dec;119:420-431. (PMID: 34687882)
Nucleic Acids Res. 2015 Apr 20;43(7):e47. (PMID: 25605792)
Nucleic Acids Res. 2018 Jul 2;46(W1):W60-W64. (PMID: 29912392)
Can J Physiol Pharmacol. 2022 Sep 1;100(9):834-847. (PMID: 35704943)
Mol Cell. 2023 Sep 7;83(17):3188-3204.e7. (PMID: 37683611)
Respir Med. 2025 Feb;237:107953. (PMID: 39832670)
Nucleic Acids Res. 2014 Jan;42(Database issue):D92-7. (PMID: 24297251)
J Proteome Res. 2024 Sep 6;23(9):4139-4150. (PMID: 39129220)
Nucleic Acids Res. 2017 Jan 4;45(D1):D43-D50. (PMID: 27924033)
Chembiochem. 2020 Mar 2;21(5):712-722. (PMID: 31449350)
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613. (PMID: 30476243)
Bioinformatics. 2007 Jul 15;23(14):1846-7. (PMID: 17496320)
Immun Ageing. 2016 Aug 24;13(1):25. (PMID: 27559355)
Lancet. 2022 Jun 11;399(10342):2227-2242. (PMID: 35533707)
Nat Rev Dis Primers. 2020 Mar 5;6(1):16. (PMID: 32139695)
Front Mol Biosci. 2020 Nov 24;7:565383. (PMID: 33324676)
J Exp Clin Cancer Res. 2025 Feb 07;44(1):45. (PMID: 39920772)
Int J Genomics. 2015;2015:206937. (PMID: 25834810)
Nucleic Acids Res. 2019 Jan 8;47(D1):D419-D426. (PMID: 30407594)
Nucleic Acids Res. 2000 Jan 1;28(1):27-30. (PMID: 10592173)
Curr Cardiol Rep. 2023 May;25(5):411-420. (PMID: 37074565)
Lipids Health Dis. 2017 Jan 11;16(1):5. (PMID: 28077172)
Respir Res. 2006 Apr 19;7:66. (PMID: 16620395)
Respir Res. 2018 Jun 6;19(1):92. (PMID: 29871630)
JACC Cardiovasc Imaging. 2021 Oct;14(10):1963-1973. (PMID: 34023272)
Genomics. 2015 Feb;105(2):83-9. (PMID: 25528681)
Int Immunopharmacol. 2024 Dec 25;143(Pt 3):113572. (PMID: 39515041)
Grant Information:
ZHY2023-188 Heilongjiang Chinese Medicine Administration Traditional Chinese Medicine study Projects; 2025XJJ-QNCX021 Heilongjiang University of Chinese Medicine Research Fund **Youth Innovation and Scientific Ability Cultivation Program
Contributed Indexing:
Keywords: Biomarkers; Chronic obstructive pulmonary disease; Heart failure; Immune infiltration; PRDEGs
Substance Nomenclature:
0 (Receptors, Pattern Recognition)
Entry Date(s):
Date Created: 20260106 Date Completed: 20260203 Latest Revision: 20260206
Update Code:
20260206
PubMed Central ID:
PMC12868864
DOI:
10.1038/s41598-025-34671-3
PMID:
41491714
Database:
MEDLINE

Weitere Informationen

Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are major health issues causing high hospitalization and mortality rates. Pattern recognition receptor-related differentially expressed genes (PRDEGs) play a crucial role in disease progression, as their altered expression patterns are closely linked to immune responses, inflammatory processes, and tissue remodeling. Understanding PRDEGs is vital for effective diagnostics and therapies. This study incorporated four GEO datasets (GSE57338, GSE16499, GSE76925, and GSE57148). Among them, GSE57338 and GSE76925 served as the primary analysis sets for HF and COPD, respectively, where differential expression, functional enrichment, and immune infiltration analyses were performed. GSE16499 and GSE57148 were used as independent validation sets to confirm the key findings. Seven PRDEGs, including PTX3, UCHL1, IL1R1, PLA2G2A, CXCL12, SPP1, and CD24, which exhibited significant expression differences in both HF and COPD. Enrichment analysis revealed that these genes were primarily associated primarily with biological processes such as the regulation of cellular extravasation and leukocyte migration, as well as the NF-kappa B signaling pathway. Immune infiltration analysis indicated significant differences in the abundances of various immune cells in HF and COPD samples. This study identified 7 PRDEGs as biomarkers, emphasizing the need to explore key genes and pathways in HF and COPD, along with 9 immune cell types and 2 signaling pathways, suggesting immune modulation's role in treatment.
(© 2026. The Author(s).)

Declarations. Competing interests: The authors declare no competing interests.