• Indocyanine Green Retention Ra...

*Result*: Indocyanine Green Retention Rate at 15 Minutes as a Key Predictor of Clinically Significant Portal Hypertension in Cirrhosis: Development and Validation of a Superior Non-Invasive Diagnostic Model.

Title:
Indocyanine Green Retention Rate at 15 Minutes as a Key Predictor of Clinically Significant Portal Hypertension in Cirrhosis: Development and Validation of a Superior Non-Invasive Diagnostic Model.
Authors:
Hu H; Zhejiang Chinese Medical University, Zhejiang, China., Lai W; Zhejiang Chinese Medical University, Zhejiang, China., Zhou T; Zhejiang Chinese Medical University, Zhejiang, China., Zhu J; Zhejiang Chinese Medical University, Zhejiang, China., Yan H; Department of Infectious Diseases, Affiliated Shulan (Hangzhou) Hospital, Shulan International Medical College, Zhejiang Shuren University, Zhejiang, China.
Source:
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology [Turk J Gastroenterol] 2025 Oct 10; Vol. 37 (2), pp. 215-222. Date of Electronic Publication: 2025 Oct 10.
Publication Type:
Journal Article; Validation Study
Language:
English
Journal Info:
Publisher: Aves Country of Publication: Turkey NLM ID: 9515841 Publication Model: Electronic Cited Medium: Internet ISSN: 2148-5607 (Electronic) Linking ISSN: 13004948 NLM ISO Abbreviation: Turk J Gastroenterol Subsets: MEDLINE
Imprint Name(s):
Publication: 2014- : İstanbul,Turkey : Aves
Original Publication: Ankara : Turkish Society of Gastroenterology, 1995-
MeSH Terms:
Indocyanine Green*/pharmacokinetics , Liver Cirrhosis*/complications , Liver Cirrhosis*/diagnostic imaging , Liver Cirrhosis*/metabolism , Hypertension, Portal*/diagnosis , Hypertension, Portal*/etiology , Coloring Agents*/pharmacokinetics , Predictive Learning Models*, Liver/blood supply ; Liver/diagnostic imaging ; Liver/metabolism ; Liver/pathology ; Spectrum Analysis/methods ; Biomarkers/analysis ; Prospective Studies ; Time Factors ; Portal Pressure ; Logistic Models ; Statistics, Nonparametric ; Risk Factors ; Software Validation ; ROC Curve ; Prognosis ; Predictive Value of Tests ; Clinical Relevance ; Liver Function Tests ; Humans ; Male ; Female ; Middle Aged ; Aged
Substance Nomenclature:
IX6J1063HV (Indocyanine Green)
0 (Coloring Agents)
0 (Biomarkers)
Entry Date(s):
Date Created: 20260211 Date Completed: 20260304 Latest Revision: 20260304
Update Code:
20260304
PubMed Central ID:
PMC12910292
DOI:
10.5152/tjg.2025.25155
PMID:
41669926
Database:
MEDLINE

*Further Information*

*Background/aims: To assess the correlation between indocyanine green retention rate at 15 minutes (ICG-R15), liver stiffness mea surement (LSM), and other clinical indicators in cirrhotic patients, using hepatic venous pressure gradient (HVPG) as a reference and to evaluate the predictive capability of ICG-R15 for clinically significant portal hypertension (CSPH).
Materials and Methods: From February 2023 to September 2024, 80 cirrhotic patients were recruited. Data collected included baseline information, laboratory results, HVPG measurements, and ICG-R15 via the ICG clearance test. Patients were classified into non-CSPH (n = 33) and CSPH (n = 47) groups based on HVPG. Pearson's correlation analyzed relationships between HVPG, ICG-R15, LSM, and other indicators. Logistic regression was used to identify risk factors for CSPH and develop a predictive model, evaluated by receiver operating characteristic curve.
Results: The CSPH patients showed lower white blood cell count, red blood cell count, hemoglobin, platelet count (PLT), and albumin, with higher total bilirubin (TBil), prothrombin time, LSM, and ICG-R15. Significant correlations were found between HVPG and ICG-R15 (r = 0.662) and LSM (r = 0.633) (both P < .001). The ICG-R15, LSM, PLT, and TBil were independent risk factors for CSPH. The model had an AUC of 0.947, sensitivity of 78.72%, and specificity of 96.97%.
Conclusion: The ICG-R15 is a significant predictor of CSPH, and a model incorporating ICG-R15 can effectively assess disease severity and predict prognosis in cirrhotic patients.   Cite this article as: Hu H, Lai W, Zhou T, Zhu J, Yan H. Indocyanine green retention rate at 15 minutes as a key predictor of clinically significant portal hypertension in cirrhosis: development and validation of a superior non-invasive diagnostic model. Turk J Gastroenterol. 2026;37(2):215-222.*