• MPI-Guided Photothermal Therap...

*Result*: MPI-Guided Photothermal Therapy of Prostate Cancer Using Stem Cell Delivery of Magnetotheranostic Nanoflowers.

Title:
MPI-Guided Photothermal Therapy of Prostate Cancer Using Stem Cell Delivery of Magnetotheranostic Nanoflowers.
Authors:
Ghaemi B; The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Rosu A; The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Kuddannaya S; The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Laurent G; Université Marie et Louis Pasteur, CNRS, Chrono-environnement (UMR 6249), Besançon, France., Bazzi R; Université Marie et Louis Pasteur, CNRS, Chrono-environnement (UMR 6249), Besançon, France., Roux S; Université Marie et Louis Pasteur, CNRS, Chrono-environnement (UMR 6249), Besançon, France., Shakeri-Zadeh A; The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Bulte JWM; The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Chemical & Biomolecular Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, Maryland, USA.; Department of Oncology, Johns Hopkins University, Baltimore, Maryland, USA.; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Inc., Baltimore, Maryland, USA.
Source:
Advanced functional materials [Adv Funct Mater] 2026 Jan 19. Date of Electronic Publication: 2026 Jan 19.
Publication Model:
Ahead of Print
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101190390 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1616-301X (Print) Linking ISSN: 1616301X NLM ISO Abbreviation: Adv Funct Mater
Imprint Name(s):
Original Publication: Weinheim, Germany : Wiley-VCH, c2001-
Grant Information:
UH2 EB028904 United States EB NIBIB NIH HHS; UH3 EB028904 United States EB NIBIB NIH HHS; S10 OD026740 United States OD NIH HHS; R01 CA257557 United States CA NCI NIH HHS; P41 EB024495 United States EB NIBIB NIH HHS; R01 EB030376 United States EB NIBIB NIH HHS
Contributed Indexing:
Keywords: magnetic particle imaging; mesenchymal stem cell; photothermal therapy; prostate cancer; theranostic nanoparticle
Entry Date(s):
Date Created: 20260225 Latest Revision: 20260226
Update Code:
20260226
PubMed Central ID:
PMC12928986
DOI:
10.1002/adfm.202521864
PMID:
41736719
Database:
MEDLINE

*Further Information*

*The efficacy of photothermal therapy (PTT) of cancer critically depends on widespread nanoparticle (NP) distribution and retention within the tumor. However, intratumoral (i.t.) injection of naked NPs may result in poor dispersion and backflow resulting in leakage and rapid clearance, limiting therapeutic outcome and increasing off-target toxicity. To overcome these limitations, we employed tumor-tropic human mesenchymal stem cells (hMSCs) as delivery vehicles for magnetotheranostic gold-iron oxide nanoflowers (GIONF), enabling widespread i.t. distribution and sustained retention in contrast to injection of naked GIONF. GIONF-hMSCs demonstrated superior heating performance under near-infrared laser irradiation while exhibiting a strong magnetic particle imaging (MPI) signal, allowing for noninvasive quantitative tracking of their whole body biodistribution. Laser irradiation at peak GIONF-hMSC retention resulted in complete tumor ablation without recurrence up to 90 days post-treatment. These results are a first demonstration of using MPI to evaluate the retention and leakage of i.t.-injected intracellular versus naked nanoparticles for advancing PTT with cellular magnetotheranostics.*

*Conflicts of Interest J.W.M.B. is a shareholder of SuperBranche. This arrangement has been reviewed and approved by the Johns Hopkins University in accordance with its conflict of interest policies. S.R. is a co-founder and shareholder of Nano-H and ORINOVA. All others have nothing to disclose.*