Treffer: Methods for Prioritizing Causal Genes in Molecular Studies of Human Disease: The State of the Art.

Methods for Prioritizing Causal Genes in Molecular Studies of Human Disease: The State of the Art.

Patasova K; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK., Sedaghati-Khayat B; Department of Rheumatology, Leiden University Medical Center, Leiden, South Holland, Netherlands., Knevel R; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK.; Department of Rheumatology, Leiden University Medical Center, Leiden, South Holland, Netherlands.; The Delft Bioinformatics Lab, Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, South Holland, Netherlands., Cordell HJ; Population Health Sciences Institute, Faculty of Medical Sciences, International Centre for Life, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK., Pratt AG; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK.; Musculoskeletal Unit, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, Tyne and Wear, UK.

Genetic epidemiology [Genet Epidemiol] 2026 Apr; Vol. 50 (3), pp. e70037.

Journal Article; Review

English

Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8411723 Publication Model: Print Cited Medium: Internet ISSN: 1098-2272 (Electronic) Linking ISSN: 07410395 NLM ISO Abbreviation: Genet Epidemiol Subsets: MEDLINE

Publication: New York, NY : Wiley-Liss
Original Publication: New York, N.Y. : Alan R. Liss, c1984-

Genome-Wide Association Study*/methods , Mendelian Randomization Analysis*/methods, Heart Diseases/genetics ; Humans ; Linkage Disequilibrium ; Genetic Predisposition to Disease ; Causality ; Models, Genetic ; Polymorphism, Single Nucleotide ; Genetic Pleiotropy

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101080711 European Union's Horizon grants; 40-00703-97-19069 ZonMw Klinische Fellow; 09120012110075 ZonMw Open Competitie

Keywords: Mendelian randomization; causal inference; causal network; colocalization

Date Created: 20260302 Date Completed: 20260307 Latest Revision: 20260307

20260308

PMC12952701

10.1002/gepi.70037

41770856

MEDLINE