Treffer: Accessible tools for biomolecular data analysis using large-scale knowledge graphs
Title:
Accessible tools for biomolecular data analysis using large-scale knowledge graphs
Authors:
Contributors:
Wolkenhauer, Olaf (gnd: 133515931) AkademischeR BetreuerIn, Repsilber, Dirk (gnd: 1065633742) AkademischeR BetreuerIn, Niarakis, Anna (gnd: 1239854595) AkademischeR BetreuerIn, Universität Rostock (gnd: 38329-6) Grad-verleihende Institution, Universität Rostock. Fakultät für Informatik und Elektrotechnik (gnd: 10085032-7) Grad-verleihende Institution
Publisher Information:
Universität Rostock Rostock
Publication Year:
2024
Collection:
Rostock University: RosDok - Rostocker Dokumentenserver
Subject Terms:
Document Type:
Dissertation
doctoral or postdoctoral thesis
Language:
unknown
DOI:
10.18453/rosdok_id00005086
Availability:
Rights:
CC BY-NC-SA 4.0 ; open access
Accession Number:
edsbas.B3A5193D
Database:
BASE
Weitere Informationen
The interpretation of biomolecular data is often challenging due to the heterogeneity in the structural and functional organization of biological systems. In this thesis, I created knowledge graphs of disease processes, published as interactive Disease Maps, and developed new tools for their analysis. I present (i) the Atlas of Inflammation Resolution (AIR), (ii) the two-dimensional enrichment analysis (2DEA) as a novel network-based enrichment approach, (iii) the Sarcopenia Map linking gastrointestinal diseases and sarcopenia, and (iv) the MASLD Map investigating steatotic liver diseases.